Environmental arsenic exposure, selenium and sputum alpha-1 antitrypsin

Environmental Arsenic Exposure and Microbiota in Induced Sputum

Arsenic exposure from drinking water is associated with adverse respiratory outcomes, but it is unknown whether arsenic affects pulmonary microbiota. This exploratory study assessed the effect of exposure to arsenic in drinking water on bacterial diversity in the respiratory tract of non-smokers. Induced sputum was collected from 10 subjects with moderate mean household water arsenic concentrat...

ALPHA-1-ANTITRYPSIN DEFICIENCY Neutrophilic inflammation and IL-8 levels in induced sputum of alpha-1-antitrypsin PiMZ subjects

Background: Severe alpha-1-antitrypsin deficiency (AATD), due to homozygosity for the protease inhibitor (Pi) Z allele, is a genetic risk factor for chronic obstructive pulmonary disease (COPD). In a previous study the sputum of severe AATD subjects with airflow obstruction showed a pattern of cellular inflammation similar to COPD patients. It is uncertain whether heterozygotes for the Z allele...

Alpha 1 antitrypsin deficiency.

Alpha-1 antitrypsin deficiency is an inherited disorder that may cause severe lung and liver disease.

Environmental arsenic exposure and diabetes.

Variability of Sputum Inflammatory Mediators in COPD and Alpha‐1‐Antitrypsin Deficiency

Background: There is inherent daily variability of sputum inflammatory mediators in stable state patients with usual COPD. The variability of pulmonary inflammation in patients with alpha‐1‐antitrypsin deficiency (A1ATD) is unknown. The current study aimed to quantify this variability, in comparison to patients with usual COPD, in order to facilitate power calculations for proof of concept tria...